Subclinical hypothyroidism and the metabolic syndrome:A meta-analysis of cross-sectional studies

更新时间:2023-08-14

【摘要】AIM: To determine the relationship between subclinical hypothyroidism(SCH) and the metabolic syndrome(MS). METHODS: We performed a systematic search of databases [MEDLINE(July 1950 to July 2012), EMBASE(July 1966 to July 2012)] and the references of identified studies. Completely published cross-sectional studies of a general population involving SCH and the MS were included. The pooled odds ratio and weighted mean difference(WMD) for the outcomes were calculated using random-effects models.RESULTS: Six cross-sectional studies with 19546 participants were included. In total, 398 of 1324 participants(30.06%) in the SCH group had the MS compared with 4975 of 18222 participants(27.30%) in the euthyroid group [OR = 1.20; 95%CI: 1.05-1.36; P = 0.004; χ2 = 2.53(P = 0.773); I2 = 0%]. Further analysis of the components of the MS showed that SCH was associatedwith increased body mass index(WMD, 0.32 kg/m; 95%CI: 0.04-0.61; P = 0.026), systolic blood pressure(WMD, 2.62 mmH g; 95%CI: 1.35-3.89; P < 0.001) and triglyceride(WMD, 0.25 mmol/L; 95%CI: 0.23-0.28; P < 0.001).CONCLUSION: Based on the cross-sectional data, SCH may be associated with an increased risk of the MS, which could be attributed to the increased risk of metabolic components.

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